Your mission
Looking to learn about the fast-growing gene therapy field?
Did you know that gene therapy focuses on treating diseases by altering genes in target organs? It could be a lifesaving one-off treatment!
At MeiraGTx we are focused on developing gene therapy treatments for patients living with serious diseases of the eye, salivary gland and central nervous system. We have a diverse product pipeline, core viral vector engineering and development expertise, in-house GMP manufacturing, and closely connected teams working together, all of which will allow you to see and experience different sides to the R&D process and the company itself whilst learning from the experts in the field.
Job Description
Project description
Process Development at MeiraGTx combines a solid understanding of chemical and biological processes with state of the art experimental and computational tools to rapidly develop robust and scalable manufacturing processes. Process Development interns work within a tight-knit team but are expected to take personal responsibility for producing results and supporting their own ideas.
The successful candidate will focus on the development of upstream unit operations for the manufacturing of novel AAV gene therapies, taking novel products from initial process development through to technology transfer to manufacturing.
During the placement you will:
- Collaborate in the development of AAV manufacturing operations, using various scale down models such as cell culture plates, flasks and stirred tank bioreactors.
- Participate in the optimization of a gene screening workflow to support cell line development, including but not limited to target selection, cloning, testing of gene modulation constructs, and gene expression analysis via RT-qPCR.
- Gain an understanding of GMP and QbD considerations in a large-scale manufacturing environment.
- Use statistical and modelling software and tools, such as DoE, statistical tests (ANOVA, t-test), and programming tools (Excel VBA).
- Gain an understanding of in-process assays such as qPCR, ELISA, plate-based spectrometric assays.
- Have access to cutting edge technology including high throughput automated tools.
- Drive innovation and challenge conventional assumptions such as the use of new process technologies.
- Collaborate and communicate with multidisciplinary teams: downstream, analytical, technology transfer and manufacturing, to plan your experiments and share the data.
Benefits- A yearly salary of £25,000.
- Extensive training on upstream unit operations for AAV manufacturing, including but not limited to seed train, cell expansion in bioreactors using fed-batch and perfusion, transfection, harvest and primary recovery.
- Free coding training courses with Datacamp.
- Exposure to other departments activities like Downstream manufacturing and Analytical methods Development, upon interest.
Location: London, N1
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