We are seeking three undergraduate Juniors, Master-level, or PhD-level students, working towards a degree in biology, biochemistry, cancer biology, molecular biology, cell biology, biopharmaceutical/pharmaceutical science, biomedical science, or other related field, for a 12-week Student Intern role in Gaithersburg, MD for a May 19th - August 8th contract period.
This posting is for the following three internship projects:
Investigating and validating biomarkers of resistance to ADC payloads
- Generation and culturing of cell lines resistant to ADC payloads.
- Validate biomarkers identified from multi-omic analyses by conducting Western blots and imaging studies.
- Work with BioInfomatics/Data Sciences to compare parental cells to resistant cells.
- Use cytotoxicity assays to confirm that payload resistant cells are also resistant to ADCs conjugated with those payloads.
- Collaborate with team members and participate in meetings.
- Present project findings at the end of the internship period.
- Analyze and communicate research results to team members.
In vitro assay development for evaluation of tumor targeted conjugates
- Design, conduct, troubleshoot and analyze in vitro experiments using an array of biochemical, molecular and cellular biology techniques to validate new targets and dissect the mechanism of action of novel cancer therapeutics.
- Collaborate with team members and participate in meetings.
- Present project findings at the end of the internship period.
- Analyze and communicate research results to team members.
Deciphering mechanisms of cell surface expression and internalization of B7 immune regulators
- Design and perform experiments to study protein expression, protein internalization in advanced cell culture systems.
- Develop combination treatment with antibody-drug conjugates and characterize combination activity.
- Collaborate with team members and participate in meetings.
- Analyze and communicate research results to team members.
- Present project findings at the end of the internship period.
Position Requirements:
- Undergraduate Juniors, Master-level, or PhD-level students, working towards a degree in biology, biochemistry, biological science, cancer biology, molecular biology, cell biology, biopharmaceutical/pharmaceutical science, biomedical science or related field. **Candidates must have an expected graduation date after August 2025.
- Wet-lab and pipetting skills, liquid handling experience, and aseptic techniques knowledge.
- Tissue culture, cell-based assays, and Western Blot analyses experience is required.
- Familiarity with bioinformatics tools, immunofluorescence microscopy, flow cytometry, transfection/transduction of cells, and qPCR.
- Proficiency in Microsoft Office Suite.
- Enthusiasm for collaboration, cross-functional projects, public speaking, and presentation design.
- Ability to report onsite to Gaithersburg, MD five days a week. This role will not provide relocation assistance.
- Minimum grade point average of 3.0.